{
  "source_doi": "10.1038/s41586-025-09514-w",
  "input": "evidence/2026-09-07-epithelial-crowding-cell-extrusion/mitchell2025-fig4.xlsx",
  "input_sha256": "96ac3a5f1d3694abd913d1b6d2f685724d86958dbea8a5a5e5441cdad0256612",
  "sheet": "Figure 4E",
  "cells": "A2:B5",
  "unit": "extrusions per 1000 epithelial cells in the reported ex vivo assay",
  "control": {
    "n": 4,
    "values": [
      32.7868852,
      54.5454545,
      25.6410256,
      50.0
    ],
    "mean": 40.743341325,
    "sem": 6.877312897294951
  },
  "atp_inhibition": {
    "n": 4,
    "values": [
      63.8297872,
      122.807018,
      90.9090909,
      121.621622
    ],
    "mean": 99.791879525,
    "sem": 14.078382582575843
  },
  "ratio_of_means": 2.449280699120471,
  "mean_difference": 59.048538199999996,
  "student_unpaired_two_sided": {
    "t": -3.768642279434793,
    "df": 6.0,
    "p": 0.009303551491743842
  },
  "welch_unpaired_two_sided": {
    "t": -3.768642279434793,
    "df": 4.354660433472212,
    "p": 0.01681446704107934
  },
  "limits": [
    "Same published observations, not an independent biological replication.",
    "Figure legend labels four independent experiments; workbook does not identify the individual animals or pairing.",
    "Control observations are explicitly shared with Figure 1N, and must not be counted twice.",
    "The intervention used oligomycin A plus oxamate in ex vivo lung slices; the result does not identify the complete causal pathway."
  ]
}