{
  "source_data": {
    "rows_plotted": 78,
    "peng": {
      "Control": {
        "n": 6,
        "mean": 39.608336666666666,
        "SEM": 3.244484091630663
      },
      "DTR+ DT-": {
        "n": 5,
        "mean": 89.506008,
        "SEM": 4.035955572902654
      },
      "DTR+ DT+": {
        "n": 6,
        "mean": 72.40208333333332,
        "SEM": 4.674390278428955
      }
    },
    "peng_treated_over_injured": 0.8089075242114845,
    "peng_unit": "xlsx says mg; published Fig6E says microgram. Plot uses a dimensionless ratio, without unit conversion.",
    "apoptosis_source_prose_audit": {
      "DT-": {
        "early": {
          "n": 3,
          "mean": 11.003333333333332,
          "SEM": 0.8065220255999076,
          "prose_mean": 10.9,
          "source_minus_prose": 0.10333333333333172
        },
        "late": {
          "n": 3,
          "mean": 0.9199999999999999,
          "SEM": 0.17616280348965083,
          "prose_mean": 0.9,
          "source_minus_prose": 0.019999999999999907
        },
        "necrosis": {
          "n": 3,
          "mean": 1.3500000000000003,
          "SEM": 0.11590225767142477,
          "prose_mean": 1.3,
          "source_minus_prose": 0.050000000000000266
        },
        "sum_of_category_means": 13.273333333333332
      },
      "DT+": {
        "early": {
          "n": 3,
          "mean": 30.886666666666667,
          "SEM": 2.3295803150877714,
          "prose_mean": 29.8,
          "source_minus_prose": 1.086666666666666
        },
        "late": {
          "n": 3,
          "mean": 3.98,
          "SEM": 0.959218431849597,
          "prose_mean": 5.3,
          "source_minus_prose": -1.3199999999999998
        },
        "necrosis": {
          "n": 3,
          "mean": 2.75,
          "SEM": 0.44034077712607994,
          "prose_mean": 3.0,
          "source_minus_prose": -0.25
        },
        "sum_of_category_means": 37.61666666666667
      }
    },
    "warren": {
      "Control": {
        "n": 31,
        "mean": 0.9999999677419353,
        "SEM": 0.06691267961689226
      },
      "Club Myc increased": {
        "n": 30,
        "mean": 1.3672072666666666,
        "SEM": 0.09611713191889773
      }
    },
    "warren_mean_ratio": 1.3672073107701284
  },
  "timeline": [
    {
      "group": "female_early",
      "transplantation_day": 7,
      "endpoint_day": 21,
      "endpoint": "histology and markers",
      "days_after_transplantation": 14
    },
    {
      "group": "female_late",
      "transplantation_day": 14,
      "endpoint_day": 28,
      "endpoint": "histology and markers",
      "days_after_transplantation": 14
    },
    {
      "group": "male_early",
      "transplantation_day": 7,
      "endpoint_day": 21,
      "endpoint": "mechanics; improvement reported",
      "days_after_transplantation": 14
    },
    {
      "group": "male_late",
      "transplantation_day": 14,
      "endpoint_day": 21,
      "endpoint": "mechanics; no significant improvement",
      "days_after_transplantation": 7
    }
  ],
  "clinical_registry": {
    "nct": "NCT06081621",
    "status": "COMPLETED",
    "hasResults": false,
    "enrollment": {
      "count": 23,
      "type": "ACTUAL"
    },
    "checked": "2026-09-10"
  },
  "scope": "Source summaries and factual timelines only; no individual clinical reanalysis or optimization.",
  "source_sha256": {
    "peng-source.xlsx": "864f6c3aa409b137c0491d7c12ebac31daa7e59bc56d14bbbd73424f3c2f5784",
    "warren-source.xlsx": "073c8885aa4bf6231f22a97d359df4e3f39dce2155d9645f38a762478c139943",
    "guo2018.html": "0cacd95d1f6f8ea3b57c9720402a09b2d38f378d5798a0366ea652ec029cfb2f",
    "trial-phase2.json": "2c93e12fde0526b3f9caef39f5128e050945156d93ca3c8f11f812089d449b60"
  }
}
