{
  "hps_expression_values": 101,
  "receptor": {
    "Scrambled": {
      "n_replicates": 6,
      "mean": 1.1040513825014466,
      "SEM": 0.04368704033947554
    },
    "HPS1": {
      "n_replicates": 6,
      "mean": 1.4969912432387265,
      "SEM": 0.1169754140689326
    },
    "HPS2": {
      "n_replicates": 4,
      "mean": 1.17886599725,
      "SEM": 0.06771563799602894
    }
  },
  "coculture": {
    "Saa3": {
      "WT": {
        "n_organoid_samples": 15,
        "mean": 1.0006933333333334,
        "SEM": 0.036856800712082416
      },
      "HPS2": {
        "n_organoid_samples": 4,
        "mean": 3.1058499999999998,
        "SEM": 0.9345630837455543
      },
      "HPS2-TG": {
        "n_organoid_samples": 4,
        "mean": 1.694525,
        "SEM": 0.48792378225668265
      },
      "HPS1": {
        "n_organoid_samples": 3,
        "mean": 0.7709,
        "SEM": 0.18116468566840874
      },
      "HPS1-2": {
        "n_organoid_samples": 3,
        "mean": 1.9428666666666665,
        "SEM": 0.3486078280500566
      }
    },
    "Ccl2": {
      "WT": {
        "n_organoid_samples": 15,
        "mean": 1.1181933333333334,
        "SEM": 0.09043310469842791
      },
      "HPS2": {
        "n_organoid_samples": 4,
        "mean": 2.32905,
        "SEM": 0.3833218284505419
      },
      "HPS2-TG": {
        "n_organoid_samples": 3,
        "mean": 0.9501,
        "SEM": 0.05367842521286678
      },
      "HPS1": {
        "n_organoid_samples": 3,
        "mean": 1.1833,
        "SEM": 0.18135151869596605
      },
      "HPS1-2": {
        "n_organoid_samples": 3,
        "mean": 1.997766666666667,
        "SEM": 0.2181666055513029
      }
    },
    "Il6": {
      "WT": {
        "n_organoid_samples": 14,
        "mean": 1.0383499999999999,
        "SEM": 0.079542051736836
      },
      "HPS2": {
        "n_organoid_samples": 4,
        "mean": 2.359725,
        "SEM": 0.4685592409628335
      },
      "HPS2-TG": {
        "n_organoid_samples": 4,
        "mean": 1.7854,
        "SEM": 0.28255139650454153
      },
      "HPS1": {
        "n_organoid_samples": 3,
        "mean": 1.2536666666666667,
        "SEM": 0.17005471995148438
      },
      "HPS1-2": {
        "n_organoid_samples": 3,
        "mean": 2.4221000000000004,
        "SEM": 0.5023983711491642
      }
    }
  },
  "panther": [
    {
      "outcome": "death",
      "arm": "combination",
      "events": 8,
      "n": 77,
      "crude_percent": 10.38961038961039
    },
    {
      "outcome": "death",
      "arm": "placebo",
      "events": 1,
      "n": 78,
      "crude_percent": 1.282051282051282
    },
    {
      "outcome": "hospitalization",
      "arm": "combination",
      "events": 23,
      "n": 77,
      "crude_percent": 29.87012987012987
    },
    {
      "outcome": "hospitalization",
      "arm": "placebo",
      "events": 7,
      "n": 78,
      "crude_percent": 8.974358974358974
    }
  ],
  "stock_flow": [
    {
      "k": 0.2,
      "J": 0.2,
      "stock": 1,
      "mean_residence_time": 5.0,
      "exit_by_12": 2.4000000000000004,
      "label_remaining_at_12": 0.09071795328941247
    },
    {
      "k": 1.0,
      "J": 1.0,
      "stock": 1,
      "mean_residence_time": 1.0,
      "exit_by_12": 12.0,
      "label_remaining_at_12": 6.14421235332821e-06
    }
  ],
  "original_hashes": {
    "hps-source.xlsx": "f0a7d18fb79bc31b136a6b8418e0e3090c0fd35554e0246b15dfbaa008f02554",
    "panther2012.html": "e0eaf278233a9e595adf5b855878c18b93bae19c8d45e84aff629c4deb43806b"
  },
  "limitations": [
    "表达数据是细胞系重复/类器官样本，不是101名患者；未重分析原Ct或各样本供体关系",
    "三药联合随机比较不能拆分单成分效果，粗比例不等60周Kaplan-Meier风险",
    "占位模型只有局部恒定流入/流出，未拟合真实细胞命运或治疗窗口",
    "Shankar摘要/正文CI、交互P值及部分子组人数不一致，未画精确效应图或重跑原IV分析",
    "未进行动物、临床或药物时序优化实验"
  ]
}